Chemistry

Corequisites: MATH UN1101 Preparation equivalent to one year of high school chemistry is assumed. Students lacking such preparation should plan independent study of chemistry over the summer or take CHEM UN0001 before taking CHEM UN1403. Topics include stoichiometry, states of matter, nuclear properties, electronic structures of atoms, periodic properties, chemical bonding, molecular geometry, introduction to quantum mechanics and atomic theory, introduction to organic and biological chemistry, solid state and materials science, polymer science and macromolecular structures and coordination chemistry. Although CHEM UN1403 and CHEM UN1404 are separate courses, students are expected to take both terms sequentially. The order of presentation of topics may differ from the order presented here, and from year to year. Students must ensure they register for the recitation that corresponds to the lecture section. Please check the Directory of Classes for details.

Preparation equivalent to one year of high school chemistry is assumed. Students lacking such preparation should plan independent study of chemistry over the summer or take CHEM UN0001 before taking CHEM UN1403. Topics include stoichiometry, states of matter, nuclear properties, electronic structures of atoms, periodic properties, chemical bonding, molecular geometry, introduction to quantum mechanics and atomic theory, introduction to organic and biological chemistry, solid state and materials science, polymer science and macromolecular structures and coordination chemistry. Although CHEM UN1403 and CHEM UN1404 are separate courses, students are expected to take both terms sequentially. The order of presentation of topics may differ from the order presented here, and from year to year. 

When registering, please add your name to the wait list for the recitation corresponding to the lecture section (1405 for lecture sec 001; 1407 for lecture sec 002; 1409 for lecture sec 003; 1411 for lecture sec 004).  Information about recitation registration will be sent out before classes begin.  DO NOT EMAIL THE INSTRUCTOR. Please check the Directory of Classes for details.

Corequisites: CHEM UN1403,CHEM UN1404 An introduction to basic lab techniques of modern experimental chemistry, including quantitative procedures and chemical analysis. Students must register for a Lab Lecture section for this course (CHEM UN1501). Please check the Directory of Classes for details. Please note that CHEM UN1500 is offered in the fall and spring semesters. Mandatory lab check-in will be held during the first week of classes in both the fall and spring semesters. 

You may be asked to serve as research subjects in studies under direction of the faculty while enrolled in this course (CHEM UN1500 Sec 1, 2, 4, 6 and CHEM UN1501 Sec 1). Participation in voluntary.

Corequisites: CHEM UN1403,CHEM UN1404 An introduction to basic lab techniques of modern experimental chemistry, including quantitative procedures and chemical analysis. Students must register for a Lab Lecture section for this course (CHEM UN1501). Please check the Directory of Classes for details. Please note that CHEM UN1500 is offered in the fall and spring semesters. Mandatory lab check-in will be held during the first week of classes in both the fall and spring semesters. 

You may be asked to serve as research subjects in studies under direction of the faculty while enrolled in this course (CHEM UN1500 Sec 1, 2, 4, 6 and CHEM UN1501 Sec 1). Participation in voluntary.

Prerequisites: A grade of 5 on the Chemistry Advanced Placement exam and an acceptable grade on the Department placement exam. Corequisites: CHEM UN1507 Premedical students may take CHEM UN2045, CHEM UN2046, CHEM UN1507 and CHEM UN2545 to meet the minimum requirements for admission to medical school. This course covers the same material as CHEM UN2443-CHEM UN2444, but is intended for students who have learned the principles of general chemistry in high school OR have completed CHEM UN1604 in their first year at Columbia. First year students enrolled in CHEM UN2045-CHEM UN2046 are expected to enroll concurrently in CHEM UN1507. Although CHEM UN2045 and CHEM UN2046 are separate courses, students are expected to take both terms sequentially. A recitation section is required. Please check the Directory of Classes for details and also speak with the TA for the course.

Prerequisites: CHEM UN1404 or CHEM UN1604, CHEM UN1500 and CHEMUN2443. The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination. Although CHEM UN2443 and CHEM UN2444 are separate courses, students are expected to take both terms sequentially. Students must ensure they register for the recitation which corresponds to the lecture section. Please check the Directory of Classes for details.

Prerequisites: CHEM UN1404 or CHEM UN1604, CHEM UN1500 and CHEMUN2443. The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination. Although CHEM UN2443 and CHEM UN2444 are separate courses, students are expected to take both terms sequentially. Students must ensure they register for the recitation which corresponds to the lecture section. Please check the Directory of Classes for details.

Prerequisites: CHEM UN1404 or CHEM UN1604, CHEM UN1500 and CHEMUN2443. The principles of organic chemistry. The structure and reactivity of organic molecules are examined from the standpoint of modern theories of chemistry. Topics include stereochemistry, reactions of organic molecules, mechanisms of organic reactions, syntheses and degradations of organic molecules, and spectroscopic techniques of structure determination. Although CHEM UN2443 and CHEM UN2444 are separate courses, students are expected to take both terms sequentially. Students must ensure they register for the recitation which corresponds to the lecture section. Please check the Directory of Classes for details.

Prerequisites: CHEM BC2001 or equivalent. Credit will not be given for any course below the 3000 level after completing CHEM BC3230 or its equivalent. Corequisites: With lab, counts towards Lab Science requirement. Atomic and molecular structure; stereochemistry of organic molecules; introduction to organic reactions, reaction mechanisms, and synthesis.

Prerequisites: CHEM BC2001.

This course explores the periodic table in ways that deepen appreciation of the chemistry of the elements. It extends tools introduced in general chemistry with a particular focus on the rich and varied chemistry of the transition metal elements. Requiring only general chemistry, this course is open to students with interests in the role that metal ions play in biology, biochemistry, neuroscience and environmental science.

Prerequisites: CHEM BC3231, MATH UN1101, and permission of instructor.

Survey of topics appropriate for a student majoring in chemistry or biochemistry, including examinations of uncertainty analysis and data processing, use of basic laboratory equipment, complex equilibria (pH, solubility, etc.), advanced solution chemistry and chemical activity, and the theoretical foundations of modern techniques in electrochemistry, chromatography and analytical experimental techniques.

Prerequisites: CHEM BC3231, PHYS BC2001, PHYS BC 2002, MATH UN1102 or MATH UN1201. Introduction to the laws of thermodynamics; application primarily to ideal systems. Free energy and equilibrium. Kinetics: rate laws and mechanisms, experimental techniques.

Prerequisites: CHEM BC3231 or Permission of Instructor. Structure, bonding and spectroscopy in inorganic compounds: applications of group theory to chemistry; ligand field theory; vibrational and electronic spectroscopy of transition metal complexes; selected topics from coordination chemistry, organometallics, bioinorganic chemistry, solid state and materials chemistry, mineralogy, and biogeochemistry.

Prerequisites: (CHEM BC3230) and (CHEM BC3231) BIOL BC1502. Introduction to biochemical building blocks, macromolecules, and metabolism. Structures of amino acids, lipids, carbohydrates, nucleic acids. Protein structure and folding. Enzyme mechanisms, kinetics, allostery. Membranes and biosignaling. Catabolism and anabolism with emphasis on chemical intermediates, metabolic energy, catalysis by specific enzymes, regulation.

Prerequisites: (CHEM BC2001) General Chemistry I with lab. Corequisites: CHEM BC3230 Basic techniques of experimental organic chemistry. Principles and methods of separation, purification, and characterization of organic compounds. Selected organic reactions.

Prerequisites: (CHEM BC2001) General Chemistry I with lab. Corequisites: CHEM BC3230 Basic techniques of experimental organic chemistry. Principles and methods of separation, purification, and characterization of organic compounds. Selected organic reactions.

Prerequisites: (CHEM BC2001) General Chemistry I with lab. Corequisites: CHEM BC3230 Basic techniques of experimental organic chemistry. Principles and methods of separation, purification, and characterization of organic compounds. Selected organic reactions.

Prerequisites: (CHEM BC2001) General Chemistry I with lab. Corequisites: CHEM BC3230 Basic techniques of experimental organic chemistry. Principles and methods of separation, purification, and characterization of organic compounds. Selected organic reactions.

Prerequisites: (CHEM BC2001) General Chemistry I with lab. Corequisites: CHEM BC3230 Basic techniques of experimental organic chemistry. Principles and methods of separation, purification, and characterization of organic compounds. Selected organic reactions.

Prerequisites: (CHEM BC2001) General Chemistry I with lab. Corequisites: CHEM BC3230 Basic techniques of experimental organic chemistry. Principles and methods of separation, purification, and characterization of organic compounds. Selected organic reactions.

Prerequisites: (CHEM BC2001) General Chemistry I with lab. Corequisites: CHEM BC3230 Basic techniques of experimental organic chemistry. Principles and methods of separation, purification, and characterization of organic compounds. Selected organic reactions.

Prerequisites: CHEM BC3231 and CHEM BC3333 

Quantitative techniques in volumetric analysis, pH measurement, UV-Visible, absorption, and fluorescence spectroscopy, and chromatographic separations. Data analysis with spreadsheets.

Prerequisites: CHEM BC3231 and CHEM BC3333 

Quantitative techniques in volumetric analysis, pH measurement, UV-Visible, absorption, and fluorescence spectroscopy, and chromatographic separations. Data analysis with spreadsheets.

Prerequisites: CHEM BC3333 or 3338 and CHEM BC3253 Corequisites: CHEM BC3271 This course combines chemical synthesis, inorganic chemistry, physical chemistry, and nanoscience into experiments with an emphasis using spectroscopy to determine chemical structure and reactivity. You will gain experience with a range of instruments, techniques, calculations, and theories. Instrumentation will include UV-Visible, infrared, near-infrared, fluorescence, and Raman spectroscopy.

Prerequisites: CHEM BC3333 or 3338 and CHEM BC3253 Corequisites: CHEM BC3271 This course combines chemical synthesis, inorganic chemistry, physical chemistry, and nanoscience into experiments with an emphasis using spectroscopy to determine chemical structure and reactivity. You will gain experience with a range of instruments, techniques, calculations, and theories. Instrumentation will include UV-Visible, infrared, near-infrared, fluorescence, and Raman spectroscopy.

Prerequisites: Organic II lab (CHEM BC3333, BC3335, or equivalent); Quantitative analysis lab (BC3338, BC3340, or equivalent); Biochemistry (CHEM BC3282y, CHEM C3501, or equivalent).

Theory and application of fundamental techniques for the isolation, synthesis and characterization of biological macromolecules including proteins, lipids, nucleotides and carbohydrates. Techniques include spectroscopic analysis, gel electrophoresis, chromatography, enzyme kinetics, immunoblotting, PCR, molecular cloning and cell culture, as well as modern laboratory instrumentation, such as UV-Vis, GC-MS and HPLC.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Prerequisites: CHEM BC3328 and permission of instructor. Individual research projects at Barnard or Columbia, culminating in a comprehensive written report.

Guided exploration of chemistry research using modern library resources. Topics include: organization and evaluation of information, information ethics, the history of citation, and use of databases. Culminates in the creation of an online research guide on a specific chemistry topic, using a variety of carefully considered and annotated sources.

The goal of this course is to explore how chemical methods and concepts have impacted our ability to understand and manipulate protein structure and function. We will navigate this subject through a combination of lectures and structured discussions on research articles from the literature. The course is divided into three segments: (1) In the first part, we will review the rudiments of protein structure and function, then delve into various aspects of enzyme chemistry and polypeptide biosynthesis. (2) In the second part of the course, we will cover synthetic methods to produce and chemically modify peptides and proteins. (3) In the final part, we will discuss chemical approaches to control protein function and monitor protein activity, focusing on methods that use small molecules and mass spectrometry proteomics.