Biological Sciences

This course uses a seminar discussion format to examine the relationship between science and society from numerous perspectives, with examples from many fields of science, mostly biology and medicine, including the Covid-19 pandemic. We welcome undergraduates from all classes who are concentrating in any field: the natural and social sciences, humanities, or the arts. There are no prerequisites, other than an interest in how the scientific enterprise works and interacts with other components of our society.  

The course addresses a wide array of topics, such as: why do people choose a scientific career? why do governments and other funders support scientific work? how does science fail? why is there widespread skepticism about science? how is it represented in the arts? how are results disseminated, evaluated, and legally protected? Assignments-- mainly short articles (from newspapers and journals) and book chapters, but also a few films and novels --will be provided for each class, and every student will undertake a term project of their own choosing, with oral and written presentations, after consultations with the instructor.

Co-requisite: (strongly recommended) BIOL BC1501

This course is suitable for majors & fulfillment of pre-health requirements. A high school biology background or equivalent preparation is highly recommended.  

BIOL BC1500 & BIOL BC1502 form a 2-semester introductory biology series and do not have to be taken in a fall to spring sequence.

Detailed introduction to biological phenomena above the cellular level; development, anatomy, and physiology of plants and animals; physiological, population, behavioral, and community ecology; evolutionary theory; analysis of micro-evolutionary events; and systematics.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

Prerequisites: BIOL BC1001 or equivalent preparation. Enrollment limited to 16 students per section. Course suitable for fulfillment of premedical requirements. BIOL BC1500 as prerequisite or corequisite. A laboratory-based introduction to the major groups of living organisms; anatomy, physiology, evolution, and systematics; and laboratory techniques for studying and comparing functional adaptations.

If you are interested in biology, come hear Columbia University professors discuss their biology-related research. Find out how the body works, the latest therapies for disease and maybe even find a lab to do research in. http://www.columbia.edu/cu/biology/courses/UN1908/index.htm

Prerequisites: one year of college chemistry is required. Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. Website: http://www.columbia.edu/cu/biology/courses/c2005/index.html. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Prerequisites: one year of college chemistry is required. Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. Website: http://www.columbia.edu/cu/biology/courses/c2005/index.html. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Mendelian and molecular genetics of both eukaryotes and prokaryotes, with an emphasis on human genetics. Topics include segregation, recombination and linkage maps, cytogenetics, gene structure and function, mutation, molecular aspects of gene expression and regulation, genetic components of cancer, and genome studies.

This class focuses on how we gather reliable scientific evidence about human biology and public health. The aim is to help students better interpret and evaluate the scientific evidence that they will encounter throughout their lifetime, in primary papers but also as presented in news, advertisement, and politics. To these ends, students will be introduced to basic definitions and concepts in statistics and epidemiology, including point estimates and measures of uncertainty, p-values, error rates, association and causation, different study designs, and selection bias. Readings will draw from a textbook as well as the primary literature. The second half of the course will turn to dissecting the representation and misrepresentation of scientific evidence presented in different venues. It will draw primarily from the textbook “Calling Bullshit” and include discussions of timely examples from the news.

Prerequisites: one year of college chemistry or the written permission of either the instructor or the premedical adviser is required. Recommended as the introductory biology course for science majors who have completed a year of college chemistry and premedical students. The fundamental principles of biochemistry, molecular biology, and genetics. Website: http://www.columbia.edu/cu/biology/courses/c2005/index.html. SPS and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Prerequisites: one year of college chemistry or the written permission of either the instructor or the premedical adviser is required. Recommended as the introductory biology course for science majors who have completed a year of college chemistry and premedical students. The fundamental principles of biochemistry, molecular biology, and genetics. Website: http://www.columbia.edu/cu/biology/courses/c2005/index.html. SPS and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Prerequisite or corequisite: BIOL UN2005 or BIOL UN2401. Contemporary Biology Lab is designed to provide students with hands-on exploration of fundamental and contemporary biological tools and concepts. Activities include in depth study of mammalian anatomy and physiology through dissection and histology, as well as a series of experiments in genetics and molecular biology, with emphasis on data analysis and experimental technique.

Prerequisite or corequisite: BIOL UN2005 or BIOL UN2401. Contemporary Biology Lab is designed to provide students with hands-on exploration of fundamental and contemporary biological tools and concepts. Activities include in depth study of mammalian anatomy and physiology through dissection and histology, as well as a series of experiments in genetics and molecular biology, with emphasis on data analysis and experimental technique.

Prerequisite or corequisite: BIOL UN2005 or BIOL UN2401. Contemporary Biology Lab is designed to provide students with hands-on exploration of fundamental and contemporary biological tools and concepts. Activities include in depth study of mammalian anatomy and physiology through dissection and histology, as well as a series of experiments in genetics and molecular biology, with emphasis on data analysis and experimental technique.

Prerequisite or corequisite: BIOL UN2005 or BIOL UN2401. Contemporary Biology Lab is designed to provide students with hands-on exploration of fundamental and contemporary biological tools and concepts. Activities include in depth study of mammalian anatomy and physiology through dissection and histology, as well as a series of experiments in genetics and molecular biology, with emphasis on data analysis and experimental technique.

Prerequisite or corequisite: BIOL UN2005 or BIOL UN2401. Contemporary Biology Lab is designed to provide students with hands-on exploration of fundamental and contemporary biological tools and concepts. Activities include in depth study of mammalian anatomy and physiology through dissection and histology, as well as a series of experiments in genetics and molecular biology, with emphasis on data analysis and experimental technique.

Prerequisites: one year of biology; a course in physics is highly recommended. Lecture and recitation. This is an advanced course intended for majors providing an in depth survey of the cellular and molecular aspects of nerve cell function. Topics include: the cell biology and biochemistry of neurons, ionic and molecular basis of electrical signals, synaptic transmission and its modulation, function of sensory receptors. Although not required, it is intended to be followed by Neurobiology II (see below). The recitation meets once per week in smaller groups and emphasizes readings from the primary literature.

Prerequisites: BIOL BC1500,1501, 1502, 1503 and BIOL BC2100, or equivalent.

Transcriptome analysis, or the analysis of all expressed RNA sequences in a cell, has long been a major part of molecular biology and genetics. The modern technique of RNA-Seq has now been established as the approach for transcriptome studies and RNA-Seq analyses are ubiquitous in all areas of Biology. In this course we will cover the major technical and analytical aspects of RNA-Seq with an emphasis on the application by students to real datasets. We will cover both the original ‘Bulk RNA-Seq’ approach, where the total transcriptome of many cells are combined, and the more recent ‘single-cell RNA-Seq’ (scRNA-Seq) technology where transcriptomes of individual cells are analyzed separately. Students will learn to read and interpret journal articles that utilize RNA-Seq datasets, both bulk and single-cell, and to perform and present RNA-Seq data using publicly available datasets.

Discussion/recitation section for BIOL UN3004 Neurobiology I section 002

Discussion/recitation section for BIOL UN3004 Neurobiology I section 002

Discussion/recitation section for BIOL UN3004 Neurobiology I section 002

This laboratory course will explore fundamental techniques that are frequently utilized in modern molecular biology laboratories. A combination of experiments will provide broad exposure to several important techniques in molecular biology. Experiments include current approaches to site-directed mutagenesis, cloning by PCR, and mutation analysis. Students will pursue multiple experimental projects and will gain experience with scientific thinking and scientific communication. SPS and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form).

Prerequisites: UN2005/UN2401 and UN2006/UN2402, or the equivalent at a different institution, and Contemporary Biology Laboratory (UN2501).

Prerequisites: two semesters of a rigorous, molecularly-oriented introductory biology course (such as UN2005 and UN2006), or the instructors permission. This course will cover the basic concepts underlying the mechanisms of innate and adaptive immunity, as well as key experimental methods currently used in the field. To keep it real, the course will include clinical correlates in such areas as infectious diseases, autoimmune diseases, cancer immunotherapy and transplantation. Taking this course wont turn you into an immunologist, but it may make you want to become one, as was the case for several students last year. After taking the course, you should be able to read the literature intelligently in this rapidly advancing field. SCE and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Prerequisites: 1 year of Introductory Biology, 1 year General Chemistry, and 1st semester Organic Chemistry.  Biochemistry is the study of the chemical processes within organisms that give rise to the immense complexity of life. This complexity emerges from a highly regulated and coordinated flow of chemical energy from one biomolecule to another. This course serves to familiarize students with the spectrum of biomolecules (carbohydrates, lipids, amino acids, nucleic acids, etc.) as well as the fundamental chemical processes (glycolysis, citric acid cycle, fatty acid metabolism, etc.) that allow life to happen. The course will end with a discussion of diseases that have biochemical etiologies. In particular, this course will employ active learning techniques and critical thinking problem-solving to engage students in answering the question: how is the complexity of life possible? NOTE: While only the 1st semester of Organic Chemistry is listed as a pre-requisite, it is highly recommended that you take all of Organic Chemistry beforehand.

Introduction to the use of molecular techniques to answer questions about subcellular biological phenomena. Techniques include isolation of genomic and plasmid DNAs, restriction enzyme analysis, DNA and protein electrophoresis, bacterial transformation, and plasmid subcloning.

This course explores the components, systems, and regulatory mechanisms involved in eukaryotic cellular function. Topics include: signal transduction, translational and protein quality control, organellar and cytoskeletal dynamics, and some coordinated responses such as proliferation and programmed cell death. Throughout the course we will see how general cell biology can be specialized to achieve specific cellular functions through regulation of the basic machinery. We will also explore the cellular and molecular bases for a variety of human pathologies, with an emphasis on cancer. In addition to lecture, we will spend some time discussing the material, including selected articles from the primary literature, and learning through group presentations.

Introduction to cell biological techniques used to investigate structural, molecular, and physiological aspects of eukaryotic cells and their organization into tissues. Techniques include light and electron microscopy, cell culture, isolation of cellular organelles, protein electrophoresis, and Western Blot analysis.

To maximize their survival animals must regulate their behavior in response to external environmental cues and their own internal state. A fundamental goal of neuroscience is to understand how neural circuits in the brain function to influence behavior. The aim of this course is to highlight the neural basis of neuropeptide regulation of innate behaviors that are critical for survival and discuss modern approaches to study the neuronal control of classically studied aspects of behavior. We will explore motor control (escape responses), sensory systems (vision, taste, and olfaction), and survival behaviors (feeding, drinking, mating, and aggression). Focus will be on recent and current research, the diversity of approaches for studying it, and how this knowledge can be applied to solve scientific questions. Students will read primary scientific literature and a significant portion of the course will be presentation and discussion-based.

Introduction to animal developmental biology and its applications. This course will examine the basic mechanisms through which animal bodies organize themselves, from an integrative perspective at the levels of genes and gene networks, cell properties and behaviors, coordinated interactions of cells in developing tissues, organs and organ systems, and the role of developmental processes in morphological evolution. Topics include: fertilization, cleavage and gastrulation, establishment of body axes, neural development, organ formation, tissue and organ regeneration, stem cells and medical applications, evolution of developmental programs, and teratogenesis.

Prerequisites: BIOL BC1500, BIOL BC1501, BIOL BC1502, BIOL BC1503 or the equivalent. This course examines how mammals carry out basic functions like manipulating objects, sensing the external world, oxygenating tissues, and processing food. Emphasis is placed on (a) how the body regulates itself through the integrated action of multiple organ systems and (b) what goes awry in disease.

Prerequisites:  BIOL BC1502 + BIOL BC1503, and either BIOL BC1500 + BIOL BC1501 or NSBV BC1001 or permission from the instructor. Structure and function of neural membranes; ionic basis of membrane potential and action potential; synaptic transmission and neurochemistry; sensory transduction and processing; reflexes and spinal cord physiology; muscle structure and function; neuronal circuitry; and nervous system development.

Antimicrobial resistant bacterial infections were estimated to account for 1.27 million deaths worldwide in 2019. The goal of the seminar is to provide an in-depth analysis of this ongoing threat. Discussions will include the molecular mechanisms, epidemiology of transmission and the consequences of antimicrobial resistant infections. It will also cover current efforts to reduce the spread and emergence of these difficult to treat pathogens, both in the community and the healthcare setting. 

Prerequisites: Concurrent with registering for this course, a student must register with the department and provide a written invitation from a mentor; details of this procedure are available at http://www.columbia.edu/cu/biology/courses/w3500/index.htm. Students must register for recitations UN3510 or consult the instructor. Corequisites: BIOL UN3510 The course involves independent study, faculty-supervised laboratory projects in contemporary biology. Concurrent with registering for this course, a student must register with the department, provide a written invitation from a mentor and submit a research proposal; details of this procedure are available at http://www.columbia.edu/cu/biology/courses/w3500/index.htm. A paper summarizing results of the work is required by the last day of finals for a letter grade; no late papers will be accepted. See the course web site (above) for more details. Students can take anywhere from 2-4 points for this course.

Required for all majors who do not select the year-long Senior Thesis Research & Seminar (BIOL BC3593 & BC3594) to fulfill their senior capstone requirement. These seminars allow students to explore the primary literature in the Biological Sciences in greater depth than can be achieved in a lecture course. Attention will be focused on both theoretical and empirical work. Seminar periods are devoted to oral reports and discussion of assigned readings and student reports. Students will write one extensive literature review of a topic related to the central theme of the seminar section. Topics vary per semester and include, but are not limited to: Plant Development, Animal Development & Evolution, Molecular Evolution, Microbiology & Global Change, Genomics, Comparative & Reproductive Endocrinology, and Data Intensive Approaches in Biology.

Required for all majors who do not select the year-long Senior Thesis Research & Seminar (BIOL BC3593 & BC3594) to fulfill their senior capstone requirement. These seminars allow students to explore the primary literature in the Biological Sciences in greater depth than can be achieved in a lecture course. Attention will be focused on both theoretical and empirical work. Seminar periods are devoted to oral reports and discussion of assigned readings and student reports. Students will write one extensive literature review of a topic related to the central theme of the seminar section. Topics vary per semester and include, but are not limited to: Plant Development, Animal Development & Evolution, Molecular Evolution, Microbiology & Global Change, Genomics, Comparative & Reproductive Endocrinology, and Data Intensive Approaches in Biology.

This year-long course is open to junior and senior Biology majors and minors. Students will complete an independent research project in Biology under the guidance of a faculty mentor at Barnard or another local institution. Attendance at the weekly seminar is required. By the end of the year, students will write a scientific paper about their project and give a poster presentation about their research at the Barnard Biology Research Symposium.

Completion of this year-long course fulfills two upper-level laboratory requirements for the Biology major or minor. This course must be taken in sequence, beginning with BIOL BC3591 in the Fall and continuing with BIOL BC3592 in the Spring. Acceptance into this course requires confirmation of the research project by the course instructors. A Barnard internal mentor is required if the research project is not supervised by a Barnard faculty member. This course cannot be taken at the same time as BIOL BC3593-BIOL BC3594.

This year-long course is open to junior and senior Biology majors and minors. Students will complete an independent research project in Biology under the guidance of a faculty mentor at Barnard or another local institution. Attendance at the weekly seminar is required. By the end of the year, students will write a scientific paper about their project and give a poster presentation about their research at the Barnard Biology Research Symposium.

Completion of this year-long course fulfills two upper-level laboratory requirements for the Biology major or minor. This course must be taken in sequence, beginning with BIOL BC3591 in the Fall and continuing with BIOL BC3592 in the Spring. Acceptance into this course requires confirmation of the research project by the course instructors. A Barnard internal mentor is required if the research project is not supervised by a Barnard faculty member. This course cannot be taken at the same time as BIOL BC3593-BIOL BC3594.

This year-long course is open to senior Biology majors. Students will complete an independent research project in Biology under the guidance of a faculty mentor at Barnard or another local institution. Attendance at the weekly seminar is required. By the end of the year, students will write a scientific paper about their project and give an oral presentation about their research at the Barnard Biology Research Symposium.

Completion of this year-long course fulfills the senior capstone requirement for the Biology major. This course must be taken in sequence, beginning with BIOL BC3593 in the Fall and continuing with BIOL BC3594 in the Spring. Acceptance into this course requires confirmation of the research project by the course instructors. A Barnard internal mentor is required if the research project is not supervised by a Barnard faculty member. This course cannot be taken at the same time as BIOL BC3591-BIOL BC3592. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Similar to BIOL BC3591-BIOL BC3592, this is a one-semester course that provides students with degree credit for unpaid research without a seminar component. You may enroll in BIOL BC3597 for between 1-4 credits per semester. As a rule of thumb, you should be spending approximately 3 hours per week per credit on your research project.

A Project Approval Form must be submitted to the department each semester that you enroll in this course. Your Barnard research mentor (if your lab is at Barnard) or internal adviser in the Biology Department (if your lab is elsewhere) must approve your planned research before you enroll in BIOL BC3597. You should sign up for your mentor's section. 

This course does not fulfill any Biology major requirements.  It is open to students beginning in their first year. 

Prerequisites: genetics or molecular biology. The course covers techniques currently used to explore and manipulate gene function and their applications in medicine and the environment. Part I covers key laboratory manipulations, including DNA cloning, gene characterization, association of genes with disease, and methods for studying gene regulation and activities of gene products. Part II also covers commercial applications, and includes animal cell culture, production of recombinant proteins, novel diagnostics, high throughput screening, and environmental biosensors.

This course provides a rigorous introduction to the theory underlying widely used biophysical methods, which will be illustrated by practical applications to contemporary biomedical research problems. The course has two equally important goals. The first goal is to explain the fundamental approaches used by physical chemists to understand  the behavior of molecules and to develop related analytical tools. The second goal is to prepare students to apply these methods themselves to their own molecular biology research projects. The course will be divided into seven modules: (i) solution thermodynamics with an emphasis on application to analysis of protein structure, folding, and binding interactions; (ii) hydrodynamic methods; (iii) statistical analysis of experimental data; (iv) molecular dynamics calculations; (v) optical spectroscopy with an emphasis on fluorescence; (vi) nuclear magnetic resonance spectroscopy; and (vii) light-scattering and diffraction methods including an overview of cryogenic electron microscopy reconstruction methods. In each module, the underlying physical theories and models will be presented and used to derive the mathematical equations applied to the analysis of experimental data.  Weekly recitations will emphasize the analysis of real experimental data and understanding the applications of biophysical experimentation in published research papers.  The problem sets emphasize use of PyMOL for analysis of macromolecular structures and use of standard curve-fitting software for analysis of protein binding data; detailed tutorials on the related methods are provided in the recitation sections.  The first three modules will be covered in Biophysical Chemistry I during the fall term, while the final three  will be covered in Biophysical Chemistry II during the spring term, and treatment of molecular dynamics calculations will be divided between the two terms.

In this course, we will explore the basic biochemistry of living systems and how this knowledge can be harnessed to create new medicines. We will learn how living systems convert environmental resources into energy through metabolism, and how they use this energy and these materials to build the molecules required for the diverse functions of life. We will discuss the applications of this biochemical knowledge to mechanisms of disease and to drug discovery. We will look at examples of drug discovery related to neurodegeneration, cancer, and the SARS-CoV-2 COVID19 pandemic. This course satisfies the requirement of most medical schools for introductory biochemistry, and is suitable for advanced undergraduates, and beginning graduate students. This course is equivalent to and replaces the prior course named UN3501, and is equivalent to the course offered in the summer.

Prerequisites: two semesters of a rigorous, molecularly-oriented introductory biology course (such as UNC2005 and UN2006), or the instructor's permission. This course will cover the basic concepts underlying the mechanisms of innate and adaptive immunity, as well as key experimental methods currently used in the field. To keep it real, the course will include clinical correlates in such areas as infectious diseases, autoimmune diseases, cancer, and transplantation. Taking this course won't turn you into an immunologist, but it may make you want to become one, as was the case for several students last year. After taking the course, you should be able to read the literature intelligently in this rapidly advancing field.

The course brings together population genetics theory, empirical studies and genetic models of disease to provide an integrated perspective on the evolutionary forces that shape human variation and in particular disease risk. Our goals are to provide you with a basic toolbox with which to approach human variation data and in parallel, to expose you to cutting-edge research and to the forefront of knowledge in human population genetics. To this end, the course includes in-depth discussions of classic papers in these fields coupled with recent findings employing new technologies and approaches.

To organize the material, we rely heavily on population genetic models. We start with consideration of single sites, covering neutral models, forward and backwards in time; models of selection; mutation-selection balance and the nearly neutral theory. We then turn to linkage and linkage disequilibrium; population structure; linked selection and tests for positive selection. Finally, we provide a brief introduction to quantitative genetics and complex trait mapping from a population genetics perspective.

The format consists in alternating lectures and discussions of primary research papers. On most weeks, there will also be a section, led by the TA (which are compulsory, unless otherwise noted). Grades will be based on class participation (20%), five homework assignments (50%) and a final class presentation (30%). Students can work together on reading the papers for class discussion and presentation, but must work on their homework assignments alone.

Reading will consist of approximately one textbook chapter and two primary research papers per week. Papers will be provided as pdfs on the class website. Textbook reading for the course will be drawn primarily from “Population Genetics, A Concise Guide” by John Gillespie 2nd edition; the specific chapters will be provided as pdfs. Additional books that provide background for a number of topics in the class are: “Human Evolutionary Genetics” (2nd edition) by Jobling, Hurles, and Tyler-Smith, “Coalescent Theory” by Wakeley [harder] and “Elements of Evolutionary Genetics” by Charlesworth and Charlesworth [harder].

Prerequisites: at least 4 college-level biology or biotechnology courses. This course will introduce students to the interrelated fields of patent law, regulatory law, and contract law that are vital to the biotech and biopharmaceutical sectors. The course will present core concepts in a way that permits students to use them throughout their corporate, academic, and government careers. SCE and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf

Students conduct research related to biotechnology under the sponsorship of a mentor within the University. The student and the mentor determine the nature and extent of this independent study. In some laboratories, the student may be assigned to work with a postdoctoral fellow, graduate student or a senior member of the laboratory, who is in turn supervised by the mentor. The mentor is responsible for mentoring and evaluating the students progress and performance. Credits received from this course may be used to fulfill the laboratory requirement for the degree. Instructor permission required. Web site: http://www.columbia.edu/cu/biology/courses/g4500-g4503/index.html

Students conduct research related to biotechnology under the sponsorship of a mentor within the University. The student and the mentor determine the nature and extent of this independent study. In some laboratories, the student may be assigned to work with a postdoctoral fellow, graduate student or a senior member of the laboratory, who is in turn supervised by the mentor. The mentor is responsible for mentoring and evaluating the students progress and performance. Credits received from this course may be used to fulfill the laboratory requirement for the degree. Instructor permission required. Web site: http://www.columbia.edu/cu/biology/courses/g4500-g4503/index.html

Students conduct research related to biotechnology under the sponsorship of a mentor outside the University within the New York City Metropolitan Area unless otherwise approved by the Program. The student and the mentor determine the nature and extent of this independent study. In some laboratories, the student may be assigned to work with a postdoctoral fellow, graduate student or a senior member of the laboratory, who is in turn supervised by the mentor. The mentor is responsible for mentoring and evaluating the students progress and performance. Credits received from this course may be used to fulfill the laboratory requirement for the degree. Instructor permission required. Web site: http://www.columbia.edu/cu/biology/courses/g4500-g4503/index.html

Students conduct research related to biotechnology under the sponsorship of a mentor outside the University within the New York City Metropolitan Area unless otherwise approved by the Program. The student and the mentor determine the nature and extent of this independent study. In some laboratories, the student may be assigned to work with a postdoctoral fellow, graduate student or a senior member of the laboratory, who is in turn supervised by the mentor. The mentor is responsible for mentoring and evaluating the students progress and performance. Credits received from this course may be used to fulfill the laboratory requirement for the degree. Instructor permission required. Web site: http://www.columbia.edu/cu/biology/courses/g4500-g4503/index.html